HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 57557Generated: October 29, 2026
tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate → 1,1-Dimethylethyl 4-(4-amino-2-fluorophenyl)-1-piperazinecarboxylate
https://huagongshe.com/reaction/57557
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate | HCID 16203508 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1,1-Dimethylethyl 4-(4-amino-2-fluorophenyl)-1-piperazinecarboxylate | HCID 16203630 | — |
Reaction Steps
To a solution of tert-butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate (5 mmol) in MeOH (30 mL) was added Pd/C (1 g), then the mixture was stirred for 18 hours at 20° C. under 1 atm. H2. The reaction was filtered and concentrated to give gray yellow oil. MS (m/z): 296 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09434726B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-87e51de047cb434cb15f48580213071b |
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| Source note | uspto-grants-2016_09 |
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