3-Methylsulfonylaminophenylboronic acid → HCID 118021943, compound

HRID 575592Notes

Reaction equation

HRID 575592 reaction equation
Br[C:2]1[C:3]([CH3:11])=[C:4]([CH3:10])[C:5](=[O:9])[N:6]([CH3:8])[CH:7]=1.[CH3:12][S:13]([NH:16][C:17]1[CH:18]=[C:19](B(O)O)[CH:20]=[CH:21][CH:22]=1)(=[O:15])=[O:14]>>[CH3:8][N:6]1[C:5](=[O:9])[C:4]([CH3:10])=[C:3]([CH3:11])[C:2]([C:21]2[CH:22]=[C:17]([NH:16][S:13]([CH3:12])(=[O:14])=[O:15])[CH:18]=[CH:19][CH:20]=2)=[CH:7]1

Participants

3

Reactant 2

HCID 27735353-Methylsulfonylaminophenylboronic acidHCID 118021625HCID 118021625, compound

Product 1

HCID 118021943HCID 118021943, compound

Procedure

5-Bromo-1,3,4-trimethylpyridin-2-one was treated with [3-(methanesulfonamido)phenyl]boronic acid in a manner similar to Example 94 to give the title compound as a white solid. 1H NMR (CDCl3, 400 MHz) δ 7.42 (s, 1H), 7.39 (t, J=7.6 Hz, 1H), 7.24 (s, 1H), 7.16 (s, 1H), 7.08 (s, 1H), 7.05 (d, J=7.6 Hz, 1H), 3.59 (s, 3H), 3.06 (s, 3H), 2.19 (s, 3H), 2.06 (s, 3H). LCMS (M+H)+ 307.

Sources & evidence

ORD record
ord-98cdbb7382694c2bb2213efe1da1d9df
Source dataset
uspto-grants-2015_05
Patent number
US09034900B2

Reaction notes

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