4-Chloro-5-(2,4-difluorophenoxy)-2-(methylsulfonylmethyl)pyrimidine → US10023592, Example 148

Participants

Role	Name	HCID	Charge
Reactant	4-Chloro-5-(2,4-difluorophenoxy)-2-(methylsulfonylmethyl)pyrimidine	HCID 118022371	—
Reactant	2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-1(2H)-one	HCID 123809499	—
Product	US10023592, Example 148	HCID 118021882	—

Reaction Steps

The title compound of Example 146, step 2 was reacted with the title compound of Example 89, step 1 in a manner similar to Example 143, step 3 to give the title compound. 1H NMR (DMSO-d6, 400 MHz) δ 8.62 (s, 1H), 8.28 (d, J=8.0 Hz, 1H), 7.91 (s, 1H), 7.69-7.68 (m, 2H), 7.58-7.54 (m, 1H), 7.45-7.34 (m, 2H), 7.07-7.03 (m, 1H), 4.83 (s, 2H), 3.58 (s, 3H), 3.17 (s, 3H). LCMS: 458.1 (M+1)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09034900B2
Source dataset	uspto-grants-2015_05
ORD ID	ord-27157b1672d84669b7bc2e5e70fd57b6
Source note	uspto-grants-2015_05