HuagongsheHuagongshe Chemistry Print Report · For research reference only
US10023592, Example 146 → US10023592, Example 150
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | US10023592, Example 146 | HCID 118021343 | — |
| Reactant | 4-Chloro-5-(2,4-difluorophenoxy)-2-methylsulfonylpyrimidine | HCID 118021544 | — |
| Product | US10023592, Example 150 | HCID 118021426 | — |
Reaction Steps
The title compound of Example 149, step 3 was reacted with 3-methoxy-1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-one (see Example 146, step 3) in a manner similar to Example 149, step 4 to give the title compound. 1H NMR (CDCl3, 400 MHz) δ 8.35 (d, J=2.0 Hz, 1H), 8.18 (s, 1H), 7.70 (d, J=2.0 Hz, 1H), 7.25-7.22 (m, 1H), 7.12-7.08 (m, 1H), 7.08-7.04 (m, 1H), 3.93 (s, 3H), 3.70 (s, 3H), 3.38 (s, 3H). LCMS: 423.9 (M+1)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034900B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-a9539c948a8a411f9ef463b9bda1fbf2 |
| Source note | uspto-grants-2015_05 |