HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-(4-tert-Butoxycarbonylpiperazinyl)phenylboronic acid, pinacol ester | HCID 2795514 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine hydrochloride | HCID 71093695 | — |
Reaction Steps
A solution of tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate (500 mg, 1.29 mmol) in 5N HCl in EA (20 mL) was stirred at room temperature for 2 hours, then concentrated to give curd product as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434726B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-3c892e8553cb43cbb9610de253df6792 |
| Source note | uspto-grants-2016_09 |