Methanesulfonamide → US10023592, Example 172

Participants

Role	Name	HCID	Charge
Reactant	Methanesulfonamide	HCID 72879	—
Reactant	4-Chloro-5-(2,4-difluorophenoxy)-2-methylsulfonylpyrimidine	HCID 118021544	—
Reactant	2-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6,7,8-tetrahydroisoquinolin-1-one	HCID 123801900	—
Product	US10023592, Example 172	HCID 118021749	—

Reaction Steps

The title compound of Example 149, step 3 was reacted with the title compound of Example 163, step 3 in a manner similar to Example 163, step 4 and the resulting product was treated with MeSO2NH2 in a manner similar to Example 163, step 5 to give the title compound. 1H NMR (DMSO-d6, 400 MHz): δ 8.16 (s, 1H), 7.46 (s, 1H), 7.25-7.20 (m, 1H), 6.90-6.84 (m, 2H), 3.34 (s, 3H), 2.80 (s, 3H), 2.41-2.29 (m, 4H), 1.60-1.48 (m, 4H). LCMS: 463.1 (M+H)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09034900B2
Source dataset	uspto-grants-2015_05
ORD ID	ord-e8dbd83f12a64c9885694f927f353b22
Source note	uspto-grants-2015_05