HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-(5-Bromopyridin-2-yl)-1,4-oxazepane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 5-Bromo-2-chloropyridine | HCID 2734414 | — |
| Reactant | 1,4-Oxazepane | HCID 21873275 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 4-(5-Bromopyridin-2-yl)-1,4-oxazepane | HCID 62967486 | 92.7% |
Reaction Steps
The solution of 5-bromo-2-chloropyridine (1.5 g, 7.8 mmol), 1,4-oxazepane (1.29 g, 9.36 mmol) and K2CO3 in 15 mL of NMP was stirred at 120° C. overnight. The mixture was added to 150 mL of water, washed with EA, dried over Na2SO4, and the volatiles were removed in vacuo to give 1.86 g of 4-(5-bromopyridin-2-yl)-1,4-oxazepane. MS(m/z)=259 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434726B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-937f5186029b471ba0aeeec94578dc8a |
| Source note | uspto-grants-2016_09 |