HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-fluoro-4-(methylsulfonyl)benzene → 8-(2-Fluoro-5-methylsulfonylphenyl)-6-methylpyrido[4,3-d]pyrimidin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-fluoro-4-(methylsulfonyl)benzene | HCID 67387081 | — |
| Reactant | 2-(2-Fluoro-5-(methylsulfonyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 90416382 | — |
| Reactant | 8-Bromo-6-methylpyrido[4,3-d]pyrimidin-5(6H)-one | HCID 118021926 | — |
| Reactant | 2-Bromo-4-ethylsulfonyl-1-propoxybenzene | HCID 118022008 | — |
| Product | 8-(2-Fluoro-5-methylsulfonylphenyl)-6-methylpyrido[4,3-d]pyrimidin-5-one | HCID 118022451 | — |
Reaction Steps
2-bromo-1-fluoro-4-methylsulfonylbenzene was substituted for the title compound of Example 225, step 1 and was converted to 2-(2-fluoro-5-methylsulfonylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in a manner similar to Example 225, step 2 and then reacted with the title compound of Example 231, step 3 in a manner similar to Example 231, step 4. LCMS: 333.9 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034900B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-c05f599a8118475ea2489abb9f168ee8 |
| Source note | uspto-grants-2015_05 |