HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl orthoformate → 5-Methyl-[1,3]oxazolo[4,5-c]pyridin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 3-amino-4-hydroxy-1-methylpyridin-2(1H)-one hydrochloride | HCID 118022163 | — |
| Product | 5-Methyl-[1,3]oxazolo[4,5-c]pyridin-4-one | HCID 118021792 | 30% |
Reaction Steps
The title compound of step 3 (500 mg, 2.8 mmol) in triethyl orthoformate (10 mL) was heated to reflux for 5 h. The mixture was concentrated in vacuo at 55° C. and purified by silica gel chromatography (PE:EA=1:1) to give the title compound (130 mg, yield: 30%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034900B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-b63bf55918954016b11f02e18e5330ba |
| Source note | uspto-grants-2015_05 |