HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3-Oxazol-4-ylmethyl methanesulfonate → US10023592, Example 246
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3-Oxazol-4-ylmethyl methanesulfonate | HCID 57771124 | — |
| Reactant | Oxetan-3-ylmethyl methanesulfonate | HCID 86680078 | — |
| Reactant | 5-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-3-methyl-1H-pyridin-2-one | HCID 118021650 | — |
| Product | US10023592, Example 246 | HCID 118021855 | — |
Reaction Steps
The title compound from Example 242, step 1 was reacted in a manner similar to Example 245 except that 1,3-oxazol-4-ylmethyl methanesulfonate was substituted for oxetan-3-ylmethyl methanesulfonate to give the title compound. 1H NMR (CDCl3, 400 MHz) δ 7.82 (s, 5H), 7.52 (s, 1H), 7.01 (d, J=9.2 Hz, 1H), 5.11 (s, 2H), 3.94 (d, J=6.8 Hz, 1H), 3.06 (s, 3H), 2.21 (s, 3H), 1.27-1.24 (m, 1H), 0.68-0.65 (m, 2H), 0.37-0.36 (m, 2H). LCMS: 415.1 (M+1)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09034900B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-56bf5076dcfc4e9c80d046612103fb07 |
| Source note | uspto-grants-2015_05 |