Ethanesulfonamide → US10023592, Example 249

Participants

Role	Name	HCID	Charge
Reactant	Ethanesulfonamide	HCID 73702	—
Reactant	1-(Cyclopropylmethyl)-5-[5-(2,4-difluorophenoxy)-2-methylsulfonylpyrimidin-4-yl]-3-methylpyridin-2-one	HCID 118022059	—
Product	US10023592, Example 249	HCID 118021861	—

Reaction Steps

The title compound of Example 248, step 3 was treated with EtSO2NH2 instead of MeSO2NH2 in a manner similar to Example 248, step 4 to give the title compound. 1H NMR (CDCl3, 400 MHz) δ 9.09 (s, 1H), 8.60 (s, 1H), 8.16 (s, 1H), 8.11 (s, 1H), 7.04-6.96 (m, 2H), 6.91-6.89 (m, 1H), 3.87 (d, J=7.2 Hz, 2H), 3.64 (q, J=7.2 Hz, 2H), 2.22 (s, 3H), 1.44 (t, J=7.2 Hz, 3H), 1.25-1.23 (m, 1H), 0.62-0.60 (m, 2H), 0.38-0.37 (m, 2H). LCMS: 477.2 (M+H)+

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09034900B2
Source dataset	uspto-grants-2015_05
ORD ID	ord-c0ccf8e37f1b428096d9d4464cea6819
Source note	uspto-grants-2015_05