HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-dimethyl-1-(4-nitrophenyl)piperidine-4-carboxamide → 1-(4-aminophenyl)-N,N-dimethylpiperidine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-dimethyl-1-(4-nitrophenyl)piperidine-4-carboxamide | HCID 16370119 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-aminophenyl)-N,N-dimethylpiperidine-4-carboxamide | HCID 39349918 | 85.3% |
Reaction Steps
A solution of N,N-dimethyl-1-(4-nitrophenyl)piperidine-4-carboxamide (2.5 g, 9.01 mmol) and 0.3 g of Pd/C in 20 mL of MeOH, under H2, was stirred at room temperature for 5 hours. The mixture was filtered, and the volatiles were removed in vacuo to give 1.9 g of 1-(4-aminophenyl)-N,N-dimethylpiperidine-4-carboxamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434726B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-b7b469407947489d9cbf859dc3a5ce13 |
| Source note | uspto-grants-2016_09 |