Chloromethyl methyl sulfide → 5-Bromo-4-(cyclopropylmethoxy)-1-(methylsulfanylmethyl)pyridin-2-one

Temperature

0 °C

To a solution of the title compound from Step 2 (330 mg, 1.35 mmol) in DMF (5 mL) was added NaH (40 mg, 2 mmol, 60% in mineral oil) at 0° C. The mixture was stirred at 0° C. for 30 minutes. Then, chloromethyl methyl sulfide (131 mg, 1.35 mmol) was added. The mixture was warmed to room temperature and stirred for 5 hours. The mixture was quenched with saturated aqueous NH4Cl (30 mL) and extracted with EA (10 mL×3). The combined organic layers were washed with saturated brine (20 mL×2), dried over anhydrous Na2SO4, filtered and concentrated under vacuum. The residue was purified by column chromatography on silica gel (PE:EA=3:1) to afford the title compound (205 mg, 50%) as yellow oil. 1H NMR (CDCl3, 400 MHz) δ 7.60 (s, 1H), 5.86 (s, 1H), 4.96 (s, 1H), 3.84 (d, J=6.8 Hz, 2H), 2.17 (s, 3H), 1.32-1.25 (m, 1H), 0.70-0.67 (m, 2H), 0.41-0.39 (m, 2H).

1. temperatureThe mixture was warmed to room temperature
2. stirringstirred for 5 hours
3. customThe mixture was quenched with saturated aqueous NH4Cl (30 mL)
4. extractionextracted with EA (10 mL×3)
5. washThe combined organic layers were washed with saturated brine (20 mL×2)
6. dry with materialdried over anhydrous Na2SO4
7. filtrationfiltered
8. concentrationconcentrated under vacuum
9. customThe residue was purified by column chromatography on silica gel (PE:EA=3:1)

ORD record

ord-8f058675fbf24343abb34e834b717d7e

Source dataset

uspto-grants-2015_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09034900B2