Triethylamine → HCID 118020858, compound

Participants

Reaction Steps

150 mg (0.46 mmol) of 2-[(1,1-dioxido-1,2-thiazolidin-2-yl)methyl]-6-(trifluoromethyl)nicotinic acid and 46 mg (0.46 mmol) of 3,4-diamino-1,2,5-oxadiazole are dissolved at RT in 10 ml of CH2Cl2, and 0.32 ml (2.31 mmol) of triethylamine, 11 mg (0.09 mmol) of DMAP and 442 mg (0.69 mmol) of 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide (50% solution in THF) are added. The reaction mixture is stirred at RT for 20 h and then washed twice with 5 ml each time of water. The organic phase is dried over Na2SO4 and concentrated. The residue is purified by column chromatography (silica gel, heptane/ethyl acetate). Yield: 42 mg (22%).

Provenance & Evidence