反应详情

温度

20 °C

A suspension of (E)-tert-butyl 4-((hydroxyimino)methyl)benzyl(tetrahydro-2H-pyran-4-yl)carbamate (A-4) (1662 g, 4.97 mol) in i-PrOAc (16.6 L) is stirred at 20° C. in a reactor. N-chlorosuccinimide (730 g, 5.47 mol) is added maintaining about 20° C. The suspension is stirred at about 20° C. to complete the reaction. The suspension is diluted with water (8.3 L) and stirred to dissolve the solid. The phases are separated and the organic phase is washed with water (8.3 L). The organic phase is concentrated then diluted with i-PrOAc (831 mL). Heptane (13.3 L; 8 V) is slowly added to induce crystallization. The thick suspension is then stirred for 1 h. The solid is collected by filtration; the filter-cake is washed with heptane (2×1.6 L; 2×1 V) and dried to afford (Z)-tert-butyl 4-(chloro(hydroxyimino)methyl)benzyl(tetrahydro-2H-pyran-4-yl)carbamate (A-4-i) (1628 g; 89%, 98.0 area % purity by HPLC) as a white powder.

1. temperaturemaintaining about 20° C
2. stirringThe suspension is stirred at about 20° C.
3. customthe reaction
4. stirringstirred
5. dissolutionto dissolve the solid
6. customThe phases are separated
7. washthe organic phase is washed with water (8.3 L)
8. concentrationThe organic phase is concentrated
9. additionthen diluted with i-PrOAc (831 mL)
10. additionHeptane (13.3 L; 8 V) is slowly added
11. customcrystallization
12. stirringThe thick suspension is then stirred for 1 h
13. filtrationThe solid is collected by filtration
14. washthe filter-cake is washed with heptane (2×1.6 L; 2×1 V)
15. customdried