Trifluoroacetic acid → HCID 46219100, compound

Participants

Reaction Steps

Preparation according to preparation 15. Tert-butyl-3-(2,3-difluorophenyl)-3-methoxypyrrolidin-1-carboxylate (4.7 g, 15 mmol), dichloromethane (20 ml) and trifluoroacetic acid (5 ml). Purification on a Biotage Isolute SCX-3 SPE column (washed with methanol and eluted with methanol/triethylamine, 4:1) gave the title compound (2.71 g, 85%). The amine was converted to the hydrochloric acid salt and recrystallized from methanol/diethyl ether: M.p. 152-153° C. MS m/z (rel. intensity, 70 eV) 198 (44), 183 (95), 171 (bp), 141 (61), 127 (44).

Provenance & Evidence