Formaldehyde → 3-(3,5-Difluorophenyl)-3-methoxy-1-methyl pyrrolidine

HRID 575949Notes

Reaction equation

HRID 575949 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2([O:14][CH3:15])[CH2:13][CH2:12][NH:11][CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1.[CH2:16]=O>C(O)=O>[F:1][C:2]1[CH:3]=[C:4]([C:9]2([O:14][CH3:15])[CH2:13][CH2:12][N:11]([CH3:16])[CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 199358743-(3,5-Difluorophenyl)-3-methoxypyrrolidine

Product 1

HCID 462192243-(3,5-Difluorophenyl)-3-methoxy-1-methyl pyrrolidine

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

Preparation according to Example 16. (+3-(3,5-difluorophenyl)-3-methoxypyrrolidine (0.02 g, 0.094 mmol), formic acid (1 ml) and formaldehyde (40% solution in water, 1 ml) was heated at 85° C. for 5 h, workup according to preparation 16. MS m/z (relative intensity, 70 eV) 227 (M+, 5), 212 (32), 197 (28), 141 (45), 57 (bp).

Workup

  1. customPreparation
  2. customworkup according to preparation 16

Sources & evidence

ORD record
ord-2de7b8cca299458b9b119d356a0359c5
Source dataset
uspto-grants-2015_05
Patent number
US09035073B2

Reaction notes

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