反应详情

Preparation according to Example 25: (+)-3-(3,4-difluorophenyl)-3-methoxypyrrolidine (0.01 g, 0.047 mmol) in formic acid (1 ml) and formaldehyde (37% solution in water, 1 ml). The crude product analyzed by GCMS. Analysis showed 87% conversion. MS m/z (relative intensity, 70 eV) 227 (M+, 3), 212 (17), 197 (18), 141 (36), 57 (bp).

1. customPreparation