HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chloroperbenzoic acid → 3-(3,4-Difluorophenyl)-1-ethyl-3-methoxypyrrolidine-1-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | 3-(3,4-Difluorophenyl)-1-ethyl-3-methoxypyrrolidine | HCID 46219222 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(3,4-Difluorophenyl)-1-ethyl-3-methoxypyrrolidine-1-oxide | HCID 46219352 | — |
Reaction Steps
Preparation according to Example 32: Enantiomer 1 of 3-(3,4-difluorophenyl)-1-ethyl-3-methoxypyrrolidine (0.009 g, 0.037 mmol), dichloromethane (2 ml), 3-chloroperoxybenzoic acid (77%) (0.017 g, 0.075 mmol). The crude product was analyzed by LCMS (Qtrap, Applied Biosystems, Q1 MS), analysis showed <95% conversion: MS (m+1)/z; 258 (M+1, bp), 257 (7), 226 (3), 214 (5), 211 (3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09035073B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-a2d1e27773394aafbe9f37ca5c0c5d2e |
| Source note | uspto-grants-2015_05 |