HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trifluoroacetic acid → 3-(3-Chloro-4-fluorophenyl)-3-methoxypyrrolidine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | Tert-butyl 3-(3-chloro-4-fluorophenyl)-3-methoxypyrrolidin-1-carboxylate | HCID 67402089 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | 3-(3-Chloro-4-fluorophenyl)-3-methoxypyrrolidine | HCID 46219356 | 88% |
Reaktionsschritte
Preparation according to Preparation 15. Tert-butyl-3-(3-chloro-4-fluorophenyl)-3-methoxypyrrolidin-1-carboxylate (1.81 g, 5.5 mmol), methylene chloride (20 mL) and trifluoroacetic acid (5 mL). Purification on a Biotage Isolute SCX-3 SPE column (washed with methanol and eluted with methanol/triethylamine, 4:1) gave the title compound (1.11 g, 88%). MS m/z (rel. intensity, 70 eV) 214 (38), 199 (73), 187 (bp), 157 (40), 133 (39).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09035073B2 |
| Quelldatensatz | uspto-grants-2015_05 |
| ORD ID | ord-a14c0dcf629943dd8c58c01596667069 |
| Quellennotiz | uspto-grants-2015_05 |