HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 6-((7-Chloropyrido[4,3-b]pyrazin-5-ylamino)methyl)morpholin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 6-(Aminomethyl)morpholin-3-one | HCID 10057542 | — |
| Reactant | 5,7-Dichloropyrido(3,4-b)pyrazine | HCID 71742827 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-((7-Chloropyrido[4,3-b]pyrazin-5-ylamino)methyl)morpholin-3-one | HCID 86717377 | 34% |
Reaction Steps
A solution of 6-(aminomethyl)morpholin-3-one (130 mg, 1 mmol), 5,7-dichloropyrido[4,3-b]pyrazine (200 mg, 1 mmol) and DIEA (260 mg, 2 mmol) in THF (20 mL) was stirred at reflux overnight. After concentration, the residue was purified by column chromatography to give product as yellow solid (100 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434726B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-6f6beef96c5c4616be22ff3013f6fbdc |
| Source note | uspto-grants-2016_09 |