反应详情

441 g (3.0 mol) of ethyl-2-cyanoethylphosphinic acid (produced as in Example 5) are at 80° C. dissolved in 400 ml of toluene and admixed with 315 g (3.5 mol) of 1,4-butanediol and esterified at about 100° C. in a distillation apparatus equipped with water trap during 4 h. On completion of the esterification the toluene and excess ethyl glycol is removed in vacuo to leave 604 g (92% of theory) of 4-hydroxybutyl ethyl(2-cyanoethyl)phosphinate as colorless oil.

1. customare at 80° C.
2. customesterified at about 100° C. in a distillation apparatus
3. customequipped with water trap during 4 h
4. customOn completion of the esterification the toluene and excess ethyl glycol is removed in vacuo