Potassium Hydroxide → HCID 86707267, compound

Participants

Reaction Steps

An aqueous solution (10 mL) of potassium hydroxide (2.24 g, 40.0 mmol) was added to a suspension of N-(4-fluorophenyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide obtained (8.05 g, 20.0 mmol) in ethanol (40 mL), and the mixture was stirred at room temperature for 15 hr. The mixture was concentrated under reduced presesure and then diluted with water. While cooling in ice, 3 mol/L hydrochloric acid was added dropwise thereto to adjust the pH to 7 to 8. A precipitated solid was collected by filtration to afford the title compound as a colorless powder (6.04 g).

Provenance & Evidence