反应详情

To a solution of 4-methyl-8-nitro-2 H-1,4-benzoxazin-3(4 H)-one (415 mg, 1.99 mmol) in ethanol (10 mL) was added 10% palladium activated carbon (415 mg) at room temperature, and the mixture was stirred overnight under a hydrogen atmosphere. The reaction mixture was filtered through Celite (registered trademark), followed by washing with ethanol. The filtrate was concentrated under reduced pressure. The resulting residue was dried under reduced pressure to afford the title compound as a gray powder (314 mg).

1. filtrationThe reaction mixture was filtered through Celite (registered trademark)
2. washby washing with ethanol
3. concentrationThe filtrate was concentrated under reduced pressure
4. customThe resulting residue was dried under reduced pressure