Ethanol → HCID 86707278, compound

Participants

Reaction Steps

An aqueous solution (10 mL) of ethanol (20 mL) and potassium hydroxide (730 mg, 12.86 mmol) was added to a solution of N-[4-(3-cyclopentylpropyl)-2-fluorophenyl]-N-(4-methoxybenzyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide obtained (4.07 g, 6.43 mmol) in tetrahydrofuran (10 mL), and the mixture was stirred at room temperature for 15 hr. The mixture was diluted with water and extracted with chloroform. The organic layer was concentrated under reduced pressure, a mixed solvent of hexane and ethyl acetate (6:1) was added to the residue, and a precipitated solid was collected by filtration to afford the title compound as a colorless powder (3.11 g).

Provenance & Evidence