HCID 86707296, compound → HCID 86707295, compound

Participants

Reaction Steps

To a solution of 5-{[2-(benzyloxy)-4-fluorophenyl]sulfamoyl}-N-(4-tert-butylphenyl)-1,3-dihydro-2H-isoindole-2-carboxamide (150 mg, 0.261 mmol) in ethanol (10 mL) was added 10% palladium activated carbon (150 mg) at room temperature, and the mixture was stirred overnight under a hydrogen atmosphere. The reaction mixture was filtered through Celite (registered trademark) and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (chloroform:methanol=19:1), powdered with hexane, and then collected by filtration to afford the title compound as a brownish red powder (98.4 mg).

Provenance & Evidence