Trifluoroacetic acid → HCID 86707297, compound

Participants

Reaction Steps

Trifluoroacetic acid (0.2 mL) was added to a solution of 2-[1-(4-tert-butylphenyl)-2-methylpropan-2-yl]-N-(2,4-dimethoxybenzyl)-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide obtained (22 mg) in a mixture of anisole (1 mL) and chloroform (1 mL) while cooling in ice, and the mixture was stirred for 2.5 hr while cooling in ice. Saturated aqueous sodium hydrogen carbonate solution was added to the reaction mixture while cooling in ice and the mixture was extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate and then the desiccant was filtered off, followed by concentration under reduced pressure. The resulting residue was purified by NH silica gel column chromatography (chloroform:methanol=49:1) to afford the title compound as a colorless oil (8 mg).

Provenance & Evidence