反应详情

Under N2, to a solution of (S)-tert-butyl(1-(7-(4-morpholinophenyl)pyrido[4,3-b]pyrazin-5-yl)pyrrolidin-3-yl)methylcarbamate (150 mg, 0.31 mmol) in anhydrous THF (10 mL) was slowly added sodium hydride (49 mg, 1.22 mmol) at 0° C. The mixture was warmed up and stirred at room temperature for 0.5 h. The reaction mixture was then cooled to 0° C., and CH3I (174 mg, 1.22 mmol) was added slowly. After the completion of the addition, the reaction mixture was stirred at reflux for 4 hours, cooled to ambient temperature, quenched with H2O, and extracted with EtOAc. The combined extracts were dried and concentrated to give the title compound. MS (m/z): 505 (M+H)+.

1. customat 0° C
2. temperatureThe mixture was warmed up
3. temperatureThe reaction mixture was then cooled to 0° C.
4. additionAfter the completion of the addition
5. stirringthe reaction mixture was stirred
6. temperatureat reflux for 4 hours
7. temperaturecooled to ambient temperature
8. customquenched with H2O
9. extractionextracted with EtOAc
10. customThe combined extracts were dried
11. concentrationconcentrated