HRID57616

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2795359

4-Morpholinophenylboronic acid

C10H14BNO3

结构：CC(C)(C)OC(=O)N1CC(O)CC(CNc2nc(Cl)cc3nccnc23)C1

HCID86717368

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N1CC(O)CC(CNc2nc(-c3ccc(N4CCOCC4)cc3)cc3nccnc23)C1

HCID71113447

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the procedures of Compound 1 (B) using tert-butyl 3-((7-chloropyrido[4,3-b]pyrazin-5-ylamino)methyl)-5-hydroxypiperidine-1-carboxylate and 4-morpholinophenylboronic acid. MS (m/z): 521 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e599baed4a414dda88e024d000d4e251
来源数据集: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09434726B2
来源说明: uspto-grants-2016_09

反应 SMILES

Cl[C:2]1[N:11]=[C:10]([NH:12][CH2:13][CH:14]2[CH2:19][CH:18]([OH:20])[CH2:17][N:16]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:15]2)[C:9]2[C:4](=[N:5][CH:6]=[CH:7][N:8]=2)[CH:3]=1.[O:28]1[CH2:33][CH2:32][N:31]([C:34]2[CH:39]=[CH:38][C:37](B(O)O)=[CH:36][CH:35]=2)[CH2:30][CH2:29]1>>[OH:20][CH:18]1[CH2:19][CH:14]([CH2:13][NH:12][C:10]2[C:9]3[C:4](=[N:5][CH:6]=[CH:7][N:8]=3)[CH:3]=[C:2]([C:37]3[CH:36]=[CH:35][C:34]([N:31]4[CH2:30][CH2:29][O:28][CH2:33][CH2:32]4)=[CH:39][CH:38]=3)[N:11]=2)[CH2:15][N:16]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:17]1