D-beta-Prolinol → (R)-(1-(7-chloropyrido[4,3-b]pyrazin-5-yl)pyrrolidin-3-yl)methanol

HRID 57617Notes

Reaction equation

HRID 57617 reaction equation
[NH:1]1[CH2:5][CH2:4][C@@H:3]([CH2:6][OH:7])[CH2:2]1.Cl[C:9]1[C:18]2[C:13](=[N:14][CH:15]=[CH:16][N:17]=2)[CH:12]=[C:11]([Cl:19])[N:10]=1>>[Cl:19][C:11]1[N:10]=[C:9]([N:1]2[CH2:5][CH2:4][C@@H:3]([CH2:6][OH:7])[CH2:2]2)[C:18]2[C:13](=[N:14][CH:15]=[CH:16][N:17]=2)[CH:12]=1

Participants

3

Reactant 2

HCID 7446913D-beta-ProlinolHCID 717428275,7-Dichloropyrido(3,4-b)pyrazine

Product 1

HCID 86717383(R)-(1-(7-chloropyrido[4,3-b]pyrazin-5-yl)pyrrolidin-3-yl)methanol

Procedure

The title compound was prepared according to the procedure of Compound 1 (A) using (R)-pyrrolidin-3-ylmethanol and 5,7-dichloropyrido[4,3-b]pyrazine. MS (m/z): 265 (M+H)+.

Sources & evidence

ORD record
ord-b555adc6eeb34879819efea38cfb4cf1
Source dataset
uspto-grants-2016_09
Patent number
US09434726B2

Reaction notes

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