HuagongsheHuagongshe Chemistry Print Report · For research reference only
Borane → ethyl 7-bromo-3-(3-hydroxypropyl)-1H-indole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Borane | HCID 6331 | — |
| Reactant | ethyl 7-bromo-3-(3-ethoxy-3-oxopropyl)-1H-indole-2-carboxylate | HCID 68940416 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | ethyl 7-bromo-3-(3-hydroxypropyl)-1H-indole-2-carboxylate | HCID 68943187 | — |
Reaction Steps
To a mixture of EXAMPLE 1A (1.85 g) in THF (50 mL) was added 1M borane.THF (30 mL). The mixture was stirred at room temperature for 16 hours, quenched with methanol (10 mL) and concentrated. The concentrate was purified by flash column chromatography on silica gel with 5-25% ethyl acetate/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09035047B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-b8fb5e5297404142bfebb34bfd77fc8f |
| Source note | uspto-grants-2015_05 |