HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → ethyl 7-bromo-3-(3-oxopropyl)-1H-indole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Pyridine sulfate | HCID 11789763 | — |
| Reactant | ethyl 7-bromo-3-(3-hydroxypropyl)-1H-indole-2-carboxylate | HCID 68943187 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | ethyl 7-bromo-3-(3-oxopropyl)-1H-indole-2-carboxylate | HCID 86628021 | — |
Reaction Steps
To a cooled (0° C.) mixture of EXAMPLE 1B (3.26 g) in dichloromethane (5 mL) was added DMSO (1 mL) and triethylamine (0.835 mL) followed by pyridine sulfate (636 mg). The mixture was stirred for 2 hours, diluted with ethyl acetate (150 mL), and washed with 5% HCl, saturated NaHCO3, water and brine and dried (Na2SO4), filtered and concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09035047B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-683fb63454aa48029c3d1b63d5afa456 |
| Source note | uspto-grants-2015_05 |