Morpholino(4-nitro-3-(trifluoromethyl)phenyl)methanone → (4-Amino-3-(trifluoromethyl)phenyl)(morpholino)methanone

HRID 576261Notes

Reaction equation

HRID 576261 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[C:11]([C:18]([F:21])([F:20])[F:19])[CH:10]=2)=[O:8])[CH2:3][CH2:2]1>C(O)C.[Pd]>[NH2:15][C:12]1[CH:13]=[CH:14][C:9]([C:7]([N:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)=[O:8])=[CH:10][C:11]=1[C:18]([F:21])([F:20])[F:19]

Participants

4

Reactant 1

HCID 68936908Morpholino(4-nitro-3-(trifluoromethyl)phenyl)methanone

Product 1

HCID 62155530(4-Amino-3-(trifluoromethyl)phenyl)(morpholino)methanone

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of EXAMPLE 144A (13 g) and Pd/C (1.3 g, 10%) in ethanol (300 mL) was stirred under hydrogen at room temperature for two days. The catalyst was filtered off and the solvent was evaporated to provide the final compound.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-a1fedb24226f4d35b15c710dba55d528
Source dataset
uspto-grants-2015_05
Patent number
US09035047B2

Reaction notes

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