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Orcinol → HCID 68939274、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Orcinol | HCID 10436 | — |
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | Dibenzyl azodicarboxylate | HCID 5387121 | — |
| 反応物 | ethyl 7-bromo-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylate | HCID 68938945 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | HCID 68939274 | HCID 68939274 | — |
反応手順
A suspension of ethyl 7-bromo-3-(3-hydroxypropyl)-1H-indole-2-carboxylate (EXAMPLE 1C) (0.9 g), 5-methylbenzene-1,3-diol (1.028 g), triphenylphosphine (0.868 g), dibenzylazodicarboxylate (0.762 g) and tetrahydrofuran (40 ml) was stirred at room temperature for 19 hours. After removal of the solvent, the crude product was purified by flash chromatography silica gel, (Analogix, SF65-200 g) eluting with 0-10% ethyl acetate in hexane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09035047B2 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-547b6bf38b4e417aa28a5e9355d2cbd1 |
| 出典メモ | uspto-grants-2015_05 |