Acetic Anhydride → 1-(2,3-Dihydro-1H-inden-5-yl)ethan-1-one

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Reaction Steps

A mixture of indane (1, 12.25 mL, 0.10 mol) and Ac2O (11.34 mL, 0.12 mol) was added dropwise for 1 h to a slurry of AlCl3 (26.7 g, 0.2 mol) in DCM (100 mL) at 0° C. The reaction mixture was warmed up to room temperature and stirred for 15 h. The mixture was cooled to 0° C. and quenched by slow addition of water (20˜30 mL) and 1M HCl (50 mL). The organic layer was separated, washed with brine and saturated NaHCO3 solution, dried over anhydrous MgSO4, filtered and concentrated in vacuo. The crude product 2 was dried under high vacuum and used without further purification (16.1 g, 0.10 mol, 100%).

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