Sodium Hydroxide → HCID 71076950, compound

HRID 576357Notes

Reaction equation

HRID 576357 reaction equation
[Br:1][C:2]1[C:7]2[S:8][CH:9]=[CH:10][C:6]=2[C:5]([Cl:11])=[C:4]([C:12]([O:14]C)=[O:13])[CH:3]=1.[OH-].[Na+]>CCO>[Br:1][C:2]1[C:7]2[S:8][CH:9]=[CH:10][C:6]=2[C:5]([Cl:11])=[C:4]([C:12]([OH:14])=[O:13])[CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 71076844HCID 71076844, compound

Product 1

HCID 71076950HCID 71076950, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of methyl 7-bromo-4-chlorobenzo[b]thiophene-5-carboxylate 96 (1.06 g, 3.3 mmol) in aqueous EtOH (40 mL) was added NaOH (400 mg, 10 mmol). The reaction mixture was stirred for 3 hours at room temperature. After the reaction was completed, the volatile solvent was removed under reduced pressure, acidification with 1N HCl was accomplished. Drying with MgSO4 was followed by normal work-up with EtOAc. After evaporating volatile solvent, the residue was used without further purification in ˜88% yield.

Workup

  1. customthe volatile solvent was removed under reduced pressure, acidification with 1N HCl
  2. dry with materialDrying with MgSO4
  3. customAfter evaporating volatile solvent
  4. customthe residue was used without further purification in ˜88% yield

Sources & evidence

ORD record
ord-442c5e1c5c7247609f56d9d23daa582b
Source dataset
uspto-grants-2015_05
Patent number
US09034921B2

Reaction notes

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