反应详情

To a solution of methyl 7-bromo-4-chlorobenzo[b]thiophene-5-carboxylate 96 (1.06 g, 3.3 mmol) in aqueous EtOH (40 mL) was added NaOH (400 mg, 10 mmol). The reaction mixture was stirred for 3 hours at room temperature. After the reaction was completed, the volatile solvent was removed under reduced pressure, acidification with 1N HCl was accomplished. Drying with MgSO4 was followed by normal work-up with EtOAc. After evaporating volatile solvent, the residue was used without further purification in ˜88% yield.

1. customthe volatile solvent was removed under reduced pressure, acidification with 1N HCl
2. dry with materialDrying with MgSO4
3. customAfter evaporating volatile solvent
4. customthe residue was used without further purification in ˜88% yield