反应详情

2-(methyl(4-(trimethylstannyl)phenyl)amino)ethanol (223 mg, 0.713 mmol), (R)-tert-butyl 2-((7-chloropyrido[4,3-b]pyrazin-5-ylamino)methyl)morpholine-4-carboxylate (246 mg, 0.648 mmol), tetrakis(triphenylphosphine)palladium (150 mg, 0.13 mmol) was mixed in toluene, reacted at 100° C. overnight. Then it was filtrated and concentrated, purified by flash chromatography (PE: EA=2:1 to 1:1) to give crude product as a reddish-brown oil. And it was used without further purification.

1. customreacted at 100° C. overnight
2. filtrationThen it was filtrated
3. concentrationconcentrated
4. custompurified by flash chromatography (PE: EA=2:1 to 1:1)
5. customto give crude product as a reddish-brown oil
6. customAnd it was used without further purification