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HRID57642

反应详情

EQUATION

反应方程式

HRID 57642 的结构方程式

REACTANTS

反应物

2
结构：[CH3][Sn]([CH3])([CH3])[c]1ccc(N2CCC(O)CC2)cc1
HCID71093682

未命名化合物

结构：CC(C)(C)OC(=O)N1CCO[C@H](CNc2nc(Cl)cc3nccnc23)C1
HCID86706988

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCO[C@H](CNc2nc(-c3ccc(N4CCC(O)CC4)cc3)cc3nccnc23)C1
HCID86717400

未命名化合物

收率 27.6%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
催化剂HCID178418397

未命名化合物

结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

1-(4-(trimethylstannyl)phenyl)piperidin-4-ol (398 mg, 1.17 mmol), (R)-tert-butyl 2-((7-chloropyrido[4,3-b]pyrazin-5-ylamino)methyl)morpholine-4-carboxylate (297 mg, 0.78 mmol), tetrakis(triphenylphosphine)palladium (180 mg, 0.15 mmol) were mixed in 5 mL toluene. The mixture was reacted at 100° C. overnight. Filtrated and concentrated, purified by flash chromatography (PE:EA=1:2) to give 112 mg reddish solid.

WORKUP

后处理

  1. customThe mixture was reacted at 100° C. overnight
  2. filtrationFiltrated
  3. concentrationconcentrated
  4. custompurified by flash chromatography (PE:EA=1:2)