HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 57645Generated: October 29, 2026
(R)-tert-butyl 2-((7-(4-(2-(methylsulfonyl)ethoxy)phenyl)pyrido[4,3-b]pyrazin-5-ylamino)methyl)morpholine-4-carboxylate → (S)-7-(4-(2-(methylsulfonyl)ethoxy)phenyl)-N-(morpholin-2-yl methyl)pyrido[4,3-b]pyrazin-5-amine
https://huagongshe.com/reaction/57645
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (R)-tert-butyl 2-((7-(4-(2-(methylsulfonyl)ethoxy)phenyl)pyrido[4,3-b]pyrazin-5-ylamino)methyl)morpholine-4-carboxylate | HCID 86717405 | — |
| Solvent | Hydrogen chloride-ethyl acetate | HCID 21866389 | — |
| Product | (S)-7-(4-(2-(methylsulfonyl)ethoxy)phenyl)-N-(morpholin-2-yl methyl)pyrido[4,3-b]pyrazin-5-amine | HCID 86717404 | — |
Reaction Steps
(R)-tert-butyl 2-((7-(4-(2-(methylsulfonyl)ethoxy)phenyl)pyrido[4,3-b]pyrazin-5-ylamino)methyl)morpholine-4-carboxylate (76 mg, 0.14 mmol) was dissolved in a solution of HCl/EA (5 N, 5 mL) and stirred for 4 hours at 20° C. The reaction was concentrated and washed with sat. NaHCO3, water and brine, concentrated and purified on TLC (CH2Cl2:MeOH=5:1) to give yellow solid. MS (m/z): 444 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09434726B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-1399d028913f41bd870728c6b0c1e792 |
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| Source note | uspto-grants-2016_09 |
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