Potassium Hydroxide → HCID 23339948, compound

HRID 576462Notes

Reaction equation

HRID 576462 reaction equation
[OH-:1].[K+].[Cl-].[CH2:4]([N+:11]1([CH3:17])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>CO>[OH-:1].[CH2:4]([N+:11]1([CH3:17])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 18617903HCID 18617903, compound

Product 1

HCID 23339948HCID 23339948, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

In a 100-mL three-necked flask equipped with a condenser and a stirrer, 2.92 g of potassium hydroxide and 20 mL of methanol were weighed and added, and 10.0 g of N-benzyl-N-methylpiperidinium chloride dissolved in 23 mL of methanol was added thereto dropwise over 10 minutes. At room temperature, the mixture was stirred for 1 hour, and precipitated potassium chloride was filtrated off. To the resultant filtrate, 0.44 g of silver oxide was added, and stirred for 1 hour at room temperature. Precipitated silver chloride and unreacted silver oxide were filtrated out, thereby obtaining 43.6 g of 20% solution of N-benzyl-N-methylpiperidinium hydroxide. The solution was confirmed to be the desired substance by NMR spectrum, MS spectrum and IR spectrum thereof.

Workup

  1. customIn a 100-mL three-necked flask equipped with a condenser and a stirrer
  2. additionadded
  3. additionwas added
  4. customprecipitated potassium chloride
  5. filtrationwas filtrated off
  6. additionTo the resultant filtrate, 0.44 g of silver oxide was added
  7. stirringstirred for 1 hour at room temperature
  8. filtrationPrecipitated silver chloride and unreacted silver oxide were filtrated out

Sources & evidence

ORD record
ord-ae6ab0ec605c409f81b9b188ef26bc7d
Source dataset
uspto-grants-2015_05
Patent number
US09040219B2

Reaction notes

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