HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 576472Generated: October 30, 2026
1-Iodo-N,N-dimethylmethanamine → 1,2-Bis(dimethylaminomethyl)ferrocene
https://huagongshe.com/reaction/576472
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Iodo-N,N-dimethylmethanamine | HCID 11171399 | — |
| Reactant | cyclopenta-1,3-diene;1-cyclopenta-2,4-dien-1-yl-N,N-dimethylmethanamine;iron(2+) | HCID 15764045 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1,2-Bis(dimethylaminomethyl)ferrocene | HCID 131727266 | — |
Reaction Steps
n-Butyllithium (Aldrich, 2.5 molar in hexane, 24 ml, 54 mmol) is added to a solution of (dimethylaminomethyl)ferrocene (Aldrich, 13.13 g, 10.69 ml, 48.97 mmol) in diethyl ether (80 ml) under nitrogen at a temperature of 25° C. and the reaction mixture stirred for 4 hours. The resulting red solution is then cooled to approximately −70° C. in a dry ice/acetone bath and Eschenmosers salt (ICH2NMe2)(Aldrich, 10 g, 54 mmol) is added. The reaction is allowed to warm to room temperature and stirred overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09040445B2 |
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| Source dataset | uspto-grants-2015_05 |
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| ORD ID | ord-ef7b3a3910b1408582f57406007b65c7 |
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| Source note | uspto-grants-2015_05 |
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