Ammonia → 57366-69-5

HRID 576495Notes

Reaction equation

HRID 576495 reaction equation
F[B-](F)(F)F.[CH3:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:27]3[CH2:26][CH2:25][C:24]4[CH:28]=[CH:29][CH:30]=[CH:31][C:23]=4[C:22]=3[O+]=[C:20]3[C:15]=2[CH2:16][CH2:17][C:18]2[CH:35]=[CH:34][CH:33]=[CH:32][C:19]=23)=[CH:10][CH:9]=1.[NH3:36]>C(O)C>[CH3:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:27]3[CH2:26][CH2:25][C:24]4[CH:28]=[CH:29][CH:30]=[CH:31][C:23]=4[C:22]=3[N:36]=[C:20]3[C:15]=2[CH2:16][CH2:17][C:18]2[CH:35]=[CH:34][CH:33]=[CH:32][C:19]=23)=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 45049628HCID 45049628, compound

Product 1

HCID 180401457366-69-5Yield 91%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

16 (6.63 g, 13.9 mmol, 1 eq) was suspended in ethanol (175 mL, denaturated with 1% methylethyl ketone). Under vigorously stirring an ammonia solution (32% aqueous solution, 18.3 g NH3, 1.075 mol, 77 eq) was added dropwise and the mixture was stirred at ambient temperature for 171/2 hours to obtain a lavender suspension. The product was isolated by filtration and purified by successive washing with ethanol (250 mL). A lavender solid (91% yield) could be obtained. The compound was directly used in the next step without any further purification.

Workup

  1. additionwas added dropwise
  2. customto obtain a lavender suspension
  3. customThe product was isolated by filtration
  4. custompurified
  5. washby successive washing with ethanol (250 mL)

Sources & evidence

ORD record
ord-1b57bceab6da4dfaacfa1164c35f1fac
Source dataset
uspto-grants-2015_05
Patent number
US09040175B2

Reaction notes

Loading…