反应详情

Lithium aluminum hydride (3 g, 78.95 mmol) was placed in 1,4-dioxane (100 mL) under inert atmosphere and 9-methyl-2,3,4,5-tetrahydroazepino[4,3-b]indol-1(6H)-one (3 g, 14.018 mmol) was added, and the mixture heated to reflux for 15 h. The reaction was monitored by TLC. The reaction was quenched with saturated aqueous sodium sulfate at 0° C., and the reaction mixture filtered. The filtrate was dried over anhydrous sodium sulfate and evaporated to dryness to afford solid, which was washed with water followed by EtOAc, and dried to afford 1.25 g of the title compound.

1. additionwas added
2. temperaturethe mixture heated
3. temperatureto reflux for 15 h
4. customThe reaction was quenched with saturated aqueous sodium sulfate at 0° C.
5. filtrationthe reaction mixture filtered
6. dry with materialThe filtrate was dried over anhydrous sodium sulfate
7. customevaporated to dryness
8. customto afford solid, which
9. washwas washed with water
10. customdried