Lithium Hydroxide → HCID 178427606, compound

Participants

Reaction Steps

To a solution of compound O (2.1 g, 2.08 mmol) in THF (5 mL), H2O (5 mL) was added 2 M aq LiOH (6 mL). The reaction mixture was stirred at room temperature for 2 h. Solvents were removed in vacuo, then the residue was dissolved in water (˜50 mL), acidified with saturated aqueous NaHSO4 (˜100 ml) and extracted with EtOAc (2×100 ml). The organic layer was dried over Na2SO4 and removal of the solvent gave compound P (1.72 g, 2.08 mmol). LC-MS [M+H] 813.5 (C39H52N6O9S2+H, calc: 813.3). Compound P was used without further purification.

Provenance & Evidence