Hydrochloric Acid → HCID 178472733, compound

Participants

Reaction Steps

Compound E (7.4 g, 8.2 mmol) in DCM (24 mL) was treated with 4 M HCl in dioxane (24 mL) at ambient temperature. The reaction mixture was stirred at ambient temperature for 1 h. DCM and most of the dioxane were removed in vacuo to a total volume of ˜15 mL, and Et2O (300 mL) was added. Precipitated product was filtered off, washed with Et2O (150 mL) and hexane and finally dried in vacuo to afford compound F (6.34 g, 100% yield) as a cream solid. LC-MS [M+H] 811.4 (C34H50N8O11S2+H, calc: 811.94). Purity >95% (UV/254 nm). Compound F was used without further purification.

Provenance & Evidence