Thioglycerol → HCID 178472730, compound

Participants

Reaction Steps

To a solution of compound G (5.5 g, 6.5 mmol) in DMF (21 mL) at ambient temperature was added K2CO3 (8.9 g, 64.5 mmol) followed by thioglycerol (5.6 mL, 64.5 mmol). The reaction mixture was stirred at ambient temperature for 1 h, filtered off and DMF was removed in vacuo. The residue was diluted with water (500 mL) and extracted with EtOAc (2×300 mL) and CHCl3 (2×300 mL). Combined organic layers were dried and removal of the solvents in vacuo afforded the crude product. The crude product was purified by flash chromatography eluting with EtOAc followed by 10% MeOH in CHCl3 to afford compound H (1.3 g, 30%). LC-MS [M+H] 668.3 (C30H49N7O8S+H, calc: 667.8). Purity >95% (UV/254 nm).

Provenance & Evidence