Methyl morpholine oxide → HCID 57473823, compound

Participants

Reaction Steps

To a solution of 1-(3,5-bis(trifluoromethyl)benzyl)-3-(3-hydroxypropyl)-3-isopropylpyrrolidin-2-one (1.1 g, approximately 2.67 mmol) in CH2Cl2 (27 mL) was added tetra-n-propylammonium perruthenate (47 mg, 0.134 mmol), N-methylmorpholine N-oxide (0.626 g, 5.35 mmol) and 4 angstrom molecular sieves (0.31 g). After 30 minutes stirring, the solution was filtered through celite and concentrated to provide 3-(1-(3,5-bis(trifluoromethyl)benzyl)-3-isopropyl-2-oxopyrrolidin-3-yl)propanal as an impure dark oil that was used in step 3 without further purification. LC/MS [M+H]+=410.15. HPLC tR=1.96 min [Waters Sunfire C18 4.6×50 mm column, 3 min gradient from 10/90/0.1 MeOH/H2O/TFA to 90/10/0.1 MeOH/H2O/TFA at 4 mL/min flow rate].

Provenance & Evidence