反应详情

To a stirred solution of MeOH (25 mL) was added slowly acetyl chloride (3.5 mL). After 30 min, 2-(6-chloropyridin-3-yl)acetic acid (2.5 g) was added and the resulting reaction mixture stirred at room temperature for 2 hr. Solvents were then removed. The residue was dissolved in EtOAc and washed with 10% NaHCO3. The organic phase was dried and concentrated to afford the product (2.5 g).

1. customthe resulting reaction mixture
2. customSolvents were then removed
3. dissolutionThe residue was dissolved in EtOAc
4. washwashed with 10% NaHCO3
5. customThe organic phase was dried
6. concentrationconcentrated