HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (S)-2-((tert-butoxycarbonyl)amino)butyl methanesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | tert-butyl N-[(2S)-1-hydroxybutan-2-yl]carbamate | HCID 11263954 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | (S)-2-((tert-butoxycarbonyl)amino)butyl methanesulfonate | HCID 89537961 | 100.2% |
Reaction Steps
To an ice cold solution of (S)-tert-butyl(1-hydroxybutan-2-yl)carbamate (9.5 g, 50 mmol) and triethylamine (10.5 mL, 75 mmol) in ether (200 mL) was added methanesulfonyl chloride (4.0 mL, 50 mmol). After 1 h, water was added, and the resulting mixture was extracted with DCM, dried (Na2SO4), filtered, and concentrated to give an oil (13.4 g, 100%) which was used directly without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09040534B2 |
| Source dataset | uspto-grants-2015_05 |
| ORD ID | ord-9d3a79e277f74b61820f0c08d482b8bd |
| Source note | uspto-grants-2015_05 |