Hydrochloric Acid → HCID 86723834, compound

Participants

Reaction Steps

To a solution of 6-chloro-3-methyl-1-(3-(trifluoromethyl)phenyl)pyrimidin-2,4(1H,3H)-dione (prepared in Reference Example 56) (1.12 g) in THF (tetrahydrofuran) (30 ml) were added under nitrogen atmosphere bis(tri-tert-butyl phosphine)palladium (188 mg) and zinc diethyl (1.1 M hexane solution, 10 ml) and the resulting mixture was stirred at room temperature for twenty minutes. The reaction solutions were added into 1 N (normality) of hydrochloric acid and the resulting mixture was extracted with ethyl acetate (50 ml×2). The organic layer was washed with saturated saline (50 ml), dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to afford 6-ethyl-3-methyl-1-(3-(trifluoromethyl)phenyl)pyrimidin-2,4(1H,3H)-dione (0.94 g).

Provenance & Evidence